Search results for " alpha-Chain T-Cell Antigen Receptor"

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Longitudinal analysis of the T-cell receptor (TCR)-VA and -VB repertoire in CD8+T cells from individuals immunized with recombinant hepatitis B surfa…

2002

SUMMARYRecent studies have suggested that vaccination induces alterations in the T cell receptor (TCR) repertoire. We investigate the diversity of the TCR repertoire after immunization with a recombinant hepatitis B surface vaccine in seven healthy subjects in CD8+ T cells in peripheral blood lymphocytes. Cellular immune responses were monitored over time by sorting CD8 T cells followed by TCR-VA and -VB complementarity determining region 3 (CDR3) analysis. Frequency of individual VB families was determined by flow cytometry. TCR-VA/VB repertoires obtained from CD8+ T cells drawn after vaccination were compared to the TCR repertoire determined prior to vaccination. Monoclonal TCR transcript…

AdultMaleDNA ComplementaryReceptors Antigen T-Cell alpha-betaT cellMolecular Sequence DataImmunologychemical and pharmacologic phenomenaCD8-Positive T-LymphocytesBiologyEpitopeInterleukin 21AntigenAntibody SpecificityClinical StudiesmedicineHumansImmunology and AllergyCytotoxic T cellHepatitis B VaccinesAmino Acid SequenceLongitudinal StudiesGene Rearrangement beta-Chain T-Cell Antigen ReceptorImmunity CellularVaccines SyntheticBase SequenceT-cell receptorAntibodies Monoclonalhemic and immune systemsT lymphocyteMiddle AgedComplementarity Determining RegionsVirologymedicine.anatomical_structureImmunologyFemaleImmunizationGene Rearrangement alpha-Chain T-Cell Antigen ReceptorCD8Clinical and Experimental Immunology
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